. .

Search

caesarium

19.02.2015, 7 pm

Prof. Dr. Eberhart Zrenner
Universitätsklinikum Tübingen
"Blinde wieder sehend machen - geht das?"

Further information

caesar seminar series

03.02.2015, 2 pm

Ilona Grundwald-Kadow, PhD
Max Planck Institute of Neurobiology, Martinsried
"Chemosensation - Context-dependent neural processing of odors and tastes"
 
Further information

11.02.2015, 2 pm

Michael J. Ziller, PhD
Meissner Lab
Harvard University, Cambridge, USA
"Epigenetic dynamics during differentiation and reprogramming"
 
Further information

The Center of Advanced European Studies and Research (caesar) is a research center for neurosciences. Caesar’s research is interdisciplinary, with scientists from the neurosciences, cell biology, biochemistry, and biophysics working together on the topics of cellular signal processing and the neural foundations of animal behavior. Caesar hosts state-of-the-art research facilities, and its scientists employ kinetic methods as well as methods from the fields of microscopy, spectroscopy, and the behavioral sciences.

News

Media reports about caesar publication in eLife

"Optogenetik bringt schlappe Spermien auf Touren" -  Dagmar Wachten, head of the Minerva Research Group at caesar, gave an interview with "Deutschlandfunk".

In the Bonn local newspaper "General-Anzeiger", our science news appeared on the front page and a detailed report was published.


Shedding light on fertility – control of sperm function by optogenetics

20.01.2015. Scientists from the Center of Advanced European Studies and Research (caesar) in Bonn, an Institute of the Max Planck Society, have succeeded for the first time in controlling the function of sperm by optogenetics. They inserted a light-activated enzyme for cAMP synthesis into mouse sperm that lacked the endogenous enzyme. Sperm of these mice are usually non-motile, and the mice consequently infertile. After stimulation of these sperms with blue light, they produce cAMP, start to swim again and are even able to fertilise eggs. Using optogenetics, the scientists are now able to control not only the influx of ions into nerve cells, and thus their activity, but also signalling pathways in other cell types. [more]


Light stimulation restores flagellar beating. Flagellar waveform of sperm lacking the function SACY enzyme, but containing the light-activated bPAC, before (left) and after stimulation with blue light (right). Successive, aligned, and superimposed images creating a “stop‐motion” image, illustrating one flagellar beating cycle. Scale bar: 30 µm.

New video: Optogenetics - how to control cells with light (in German)