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IMPRS / Graduate Schools

caesar seminar series

06.10.2016, 11 am

Matias Hernandez, PhD
Max Planck Institute of Molecular Physiology, Dortmund
"Contending issues in membrane fusion: from viruses to vesicles and then to cells, and then back"

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17.10.2016, 11 am

Nathalie Jurisch-Yaksi
Centre for Neural Computation, Trondheim, Norway 
"The role of motile cilia in olfaction"

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17.10.2016, 2 pm

Emre Yaksi
Centre for Neural Computation, Trondheim, Norway 
"Studying the function and connectivity of habenular networks in zebrafish brain"

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Caesar is a Neuroscience research institute associated with the Max Planck Society. Caesar’s research is interdisciplinary with scientists from various research areas working together on the topics of cellular signal processing and the neural foundations of behavior. 


Biosensor measures signaling molecules within cilia - Scientists can measure the dynamics of signaling molecules in subcellular compartments

<b>The novel biosensor within the flagellum of mouse sperm.</b> Above, an image of a single mouse sperm acquired with a light microscope is shown. Within this image, the flagellum is marked red. The middle image displays a normal and the lower image an increased cAMP concentration along the flagellum. Whereby blue corresponds to a low and red to a high cAMP concentration. A comparison of the two images demonstrates: cAMP concentration changes differ significantly in different areas of the flagellum.

Bonn, 22.03.2016. Scientists of the Research Center caesar in Bonn, an Institute of the Max Planck Society, developed a new biosensor, which allows to measure nanomolar levels of the second messenger cAMP.  The sensor makes it possible to study cAMP signaling with high precision, even in subcellular compartments. Using this new biosensor, the scientists of the Minerva Max Planck Research Group “Molecular Physiology“ headed by Dagmar Wachten and of the Department “Molecular Sensory Systems” headed by Benjamin Kaupp revealed how the production of cAMP is regulated in the flagella of sperm cells from mice. [more]