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The 2020 motile active
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"A novel cross-species inhibitor to study the function of CatSper
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Windler, F., Bönigk, W., Körschen, H. G., Grahn, E., Strünker, T., Seifert, R. & Kaupp, U. B. (2018) "The solute carrier SLC9C1 is a Na+/H+-exchanger gated by an S4-type
voltage-sensor and cyclic-nucleotide binding"
Nature Communications 9, 2809
Brenker, C., Schiffer, C., Wagner, I.V., Tüttelmann, F., Röpke, A., Rennhack, A., Kaupp, U.B. & Strünker, T. (2018)
"Action of steroids and plant triterpenoids on
CatSper Ca2+ channels in human sperm”
Proc. Natl. Acad. Sci. USA 115, E344–E346 
Balbach, M., Beckert, V., Hansen, J.N. & Wachten, D. (2018) “Shedding light on the
role of cAMP in mammalian sperm physiology”
Mol. Cell. Endocrinol. 468, 111-120
Rennhack, A., Grahn, E., Kaupp, U.B. & Berger, T.K. (2017) “Photocontrol of the Hv1 proton
channel”
ACS Chem.Biol.12, 2952-2957
Saggiorato, G., Alvarez, L., Jikeli, J., Kaupp, U.B., Gompper, G. & Elgeti, J. (2017) “Human sperm steer with second
harmonics of the flagellar beat”
Nat. Commun. 8, 1405
Zhong, W., Ciatipis, M., Wolfenstetter, T., Jessberger, J., Müller, C., Ponsel, S., Yanovsky, Y., Brankack, J., Tort,
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“Selective entrainment of gamma subbands by different slow network
oscillations”
Proc. Natl. Acad. Sci. USA 114, 4519–1524
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sperm cell"
J. Plant. Res. 130, 455-464
Jansen, V., Jikeli, J.F., Wachten, D. (2017) "How to control cyclic
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Curr. Opin. Biotechnol. 48, 15 - 20
Schonauer, S., Körschen, H.G., Penno, A., Rennhack, A., Breiden, B., Sandhoff, K., Gutbrod, K., Dörmann, P., Raju,
D.N., Haberkant, P., Gerl, M.J., Brügger, B., Zigdon, H., Vardi, A., Futerman, A.H., Wachten, D. (2017)
"Identification
of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular
mechanisms in Gaucher disease"
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Kaupp, U.B. & Strünker, T. (2016) "Signaling in sperm: more different than similar?" Trends
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Berger, T.K., Fußhöller, D.M., Goodwin, N., Bönigk, W., Müller, A., Khesroshahi, N.D., Brenker, C., Wachten, D.,
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"Posttranslational cleavage of Hv1 in human sperm
tunes pH- and voltage-dependent gating”
J. Physiol. 595, 1533-1546
Kaupp, U.B. & Alvarez, L. (2016) "Sperm as microswimmers - navigation and sensing at the physical
limit"
Eur. Phys. J. Spec. Top. 225, 2119-2139
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M., Wachten, D., Steger, K. & Schorle, H. (2016)
"Re-visiting
the Protamine-2 locus: deletion, but not haploinsufficiency, renders male mice infertile"
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Voß, B., Seifert, R., Kaupp, U.B. & Grubmüller, H. (2016) "A quantitative model
for cAMP binding to the binding Domain of MloK1"
Biophys. J. 111, 1668-1678
Wachten, D., Jikeli, J. & Kaupp, U.B. (2016) "Sperm sensory signaling" CSH Perspect. Biol., a028225
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Actuators"
Methods Mol. Biol. 1408, 93-105
Björkgren, I., Alvarez, L., Blank, N., Balbach, M., Turunen, H., Laajala, T.D., Toivanen, J., Krutskikh, A.,
Wahlberg, N., Huhtaniemi, I., Poutanen, M., Wachten, D. & Sipilä, P. (2016)
"Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm
flagellar beat pattern and zona pellucida binding"
Mol. Cell. Endocrinol. 427, 143-154
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S., Jansen, V., Jikeli, J.F., Hamzeh, H., Alvarez, L., Dombrowski, M., Balbach, M., Strünker, T., Seifert, R.,
Kaupp, U.B. & Wachtern, D. (2016)
"A novel biosensor to study cAMP dynamics in cilia
and flagella"
eLife 5, e14052
Börger, C., Schünke, S., Lecher, J., Stoldt, M., Winkhaus, F., Kaupp, U.B. & Willbold, D. (2015) "Resonance
assignment of the ligand-free cyclic nucleotide-binding domain from the murine ion channel HCN2"
J. Biomol.
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Fechner, S., Alvarez, L., Bönigk, W., Müller, A., Berger, T., Pascal, R., Trötschel, C., Poetsch, A., Stölting, G.,
Siegfried, K.R., Seifert, R. & Kaupp, U.B. (2015)
"A K+-selective CNG
channel orchestrates Ca2+ signalling in zebrafish sperm"
eLife, e07624
Royeck, M., Kelly, T., Opitz, T., Otte, D.-M., Rennhack, A., Woitecki, A., Pitsch, J., Becer, A., Schoch, S., Kaupp,
U.B., Yaari, Y., Zimmer, A. & Beck, H. (2015)
"Downregulation of
spermine Augments dendritic persistent sodium currents and synaptic integration after status epilepticus"
J. Neurosci. 35, 15240 - 15253
Jikeli, J., Alvarez, L., Friedrich, B.M., Wilson, L.G., Pascal, R., Colin, R., Pichlo, M., Rennhack, A., Brenker, C.
& Kaupp, U.B. (2015)
"Sperm navigation along helical paths in 3D
chemoattractant landscapes"
Nat. Commun. 6, 7985
Raju, D., Schonauer, S., Hamzeh, H., Flynn, K.C., Bradke, F., vom Dorp, K., Dörmann, P., Yildiz, Y., Trötschel, C.,
Poetsch, A., Breiden, B., Sandhoff, K., Körschen, H.G. & Wachten, D. (2015)
"Accumulation of glucosylceramide in the absence of the Beta-Glucosidase GBA2
alters cytoskeletal dynamics"
PLoS Genet 11, e1005063
Scheib, U., Stehfest, K., Gee, C.E., Körschen, H.G., Fudim, R., Oertner, T.G. & Hegemann, P. (2015) "The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii
enables fast optical control of cGMP signaling"
Sci. Sinal. 8, rs8
Strünker, T., Alvarez, L. & Kaupp, U.B. (2015) "At the physical limit —
chemosensation in sperm"
Curr. Opin. Neurobiol. 34, 110-116
Strünker, T. & Kaupp, U.B. (2015) "Larry Cohen—50 ways to DYE your
science"
Neurophotonics 2, 021004-021004
Mony, L., Berger, T.K. & Isacoff, E.Y. (2015) "A specialized molecular motion opens the
Hv1 voltage-gated proton channel"
Nat. Struct. Mol. Biol. 22, 283-290
Berger, T.K. & Isacoff, E.Y. (2015) "Fluorescent Labeling for Patch-Clamp
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Methods Mol. Biol.
1266, 93-106
Gunkel, M., Schöneberg, J., Alkhaldi, W., Irsen, S., Noé, F., Kaupp, U.B. & Al-Amoudi, A. (2015) "Higher-order architecture
of rhodopsin in intact photoreceptors and its implication for phototransduction kinetics"
Structure 23,
628 - 638
Jansen, V., Alvarez, L., Balbach, M., Strünker, T., Hegemann, P., Kaupp, U.B. & Wachten, D. (2015) "Controlling fertilization and cAMP signaling
in sperm by optogenetics"
eLife 4, e05161
Seifert, R., Flick, M., Bönigk, W., Alvarez, L., Trötschel, C., Poetsch, A., Müller, A., Goodwin, N., Pelzer, P.,
Kashikar, N.D., Kremmer, E., Jikeli, J., Timmermann, B., Kuhl, H., Fridman, D., Windler, F., Kaupp, U.B. & Strünker,
T. (2015)
"The
CatSper channel controls chemosensation in sea urchin sperm"
EMBO J. 34, 379-392
Börger, C., Schünke, S., Lecher, J., Stoldt, M., Winkhaus, F., Kaupp, U.B. & Willbold, D. (2014) "Resonance
assignment of the ligand-free cyclic nucleotide-binding domain from the murine ion channel HCN2"
Biomol. NMR
Assign.
9, 243-246
Pichlo, M., Bungert-Plümke, S., Weyand, I., Seifert, R., Bönigk, W., Strünker, T., Kashikar, N.D., Goodwin, N.,
Müller, A., Pelzer, P., Van, Q., Enderlein, J., Klemm, C., Krause, E., Trotschel, C., Poetsch, A., Kremmer, E. &
Kaupp, U.B. (2014)
"High density and ligand affinity confer ultrasensitive signal
detection by a guanylyl cyclase chemoreceptor"
J. Cell. Biol. 206, 541-557
Schiffer, C., Müller, A., Egeberg, D.L., Alvarez, L., Brenker, C., Rehfeld, A., Frederiksen, H., Wäschle, B., Kaupp,
U.B., Balbach, M., Wachten, D., Skakkebaek, N.E., Almstrup, K. & Strünker, T. (2014)
"Direct action of endocrine disrupting chemicals on human sperm" EMBO
Rep.
15, 731-815
Brenker, C., Zhou, Y., Müller, A., Echeverry, F.A., Trotschel, C., Poetsch, A., Xia, X.M., Bönigk, W., Lingle, C.J.,
Kaupp, U.B. & Strünker, T. (2014)
"The Ca2+-activated K+ current of human sperm is
mediated by Slo3"
eLife 3, e01438
Mass, E., Wachten, D., Aschenbrenner, A.C., Voelzmann, A. & Hoch, M. (2014) "Murine Creld1 Controls Cardiac Development through Activation of Calcineurin/NFATc1
Signaling"
Dev. Cell 28, 711-726
Alvarez, L., Friedrich, B.M., Gompper, G. & Kaupp, U.B. (2014) "The
computational sperm cell"
Trends Cell Biol. 24, 198-207
Geißler, K.J., Jung, M.J., Riecken, L.B., Sperka, T., Cui, Y., Schacke, S., Merkel, U., Markwart, R., Rubio, I.,
Than, M.E., Breithaupt, C., Peuker, S., Seifert, R., Kaupp, U.B., Herrlich, P. & Morrison, H. (2013)
"Regulation
of Son of sevenless by the membrane-actin linker protein ezrin"
Proc. Natl. Acad. Sci. USA 110,
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Krähling, M., Alvarez, L., Debowski, K., Van, Q., Gunkel, M., Irsen, S., Al-Amoudi, A., Strünker, T., Kremmer, E.,
Krause, E., Voigt, I., Wörtge, S., Waisman, A., Weyand, I., Seifert, R., Kaupp, U.B. & Wachten, D. (2013)
"CRIS- a novel cAMP-binding protein controlling spermiogenesis and the
development of flagellar bending"
PLoS Genet.9, e1003960
Rabionet, M., Bayerle, A., Marsching, C., Jennemann, R., Grone, H.J., Yildiz, Y., Wachten, D., Shaw, W., Shayman,
J.A. & Sandhoff, R. (2013)
"1-O-Acylceramides are natural components of human and
mouse epidermis"
J. Lipid. Res. 54, 3312-3321
Hirohashi, N., Alvarez, L., Shiba, K., Fujiwara, E., Iwata, Y., Mohri, T., Inaba, K., Chiba, K., Ochi, H., Supuran,
C.T., Kotzur, N., Kakiuchi, Y., Kaupp, U.B. & Baba, S.A. (2013)
"Sperm
from Sneaker Male Squids Exhibit Chemotactic Swarming to CO2"
Curr. Biol. 23, 775-781
Peuker, S., Cukkemane, A., Held, M., Noé, F., Kaupp, U.B. & Seifert, R. (2013) "Kinetics
of ligand-receptor interaction reveals an induced-fit mode of binding in a cyclic nucleotide-activated protein"
Biophys. J. 104, 63-74
Körschen, H.G., Yildiz, Y., Raju, D.N., Schonauer, S., Bönigk, W., Jansen, V., Kremmer, E., Kaupp,
U.B. & Wachten, D. (2013)
"The non-lysosomal beta-glucosidase GBA2 is a non-integral
membrane-associated protein at the ER and Golgi"
J. Biol. Chem. 288, 3388-3393
Alvarez, L., Dai, L., Friedrich, B.M., Kashikar, N., Gregor, I., Pascal, R. & Kaupp, U.B. (2012) "The rate of
change in Ca
2+ concentration controls sperm chemotaxis" J. Cell Biol. 196, 653-663
Brenker, C., Goodwin, N., Weyand, I., Kashikar, N.D., Naruse, M., Krähling, M., Müller, A., Kaupp, U.B. & Strünker,
T. (2012)
"The
CatSper channel: a polymodal chemosensor in human sperm"
EMBO J. 31, 1654-1665
Cukkemane, A., Nand, D., Gradmann, S., Weingarth, M., Kaupp, U.B. & Baldus, M. (2012) "Solid-state NMR
[ [++13)C, (15)N] resonance assignments of the nucleotide-binding domain of a bacterial cyclic nucleotide-gated
channel"
Biomol. NMR Assign. 6, 225-229
Drawnel, F.M., Wachten, D., Molkentin, J.D., Maillet, M., Aronsen, J.M., Swift, F., Sjaastad, I., Liu, N., Catalucci,
D., Mikoshiba, K., Hisatsune, C., Okkenhaug, H., Andrews, S.R., Bootman, M.D. & Roderick, H.L. (2012)
"Mutual antagonism between IP3RII and miRNA-133a regulates
calcium signals and cardiac hypertrophy"
J. Cell Biol. 199, 783-798
Kashikar, N.D., Alvarez, L., Seifert, R., Gregor, I., Jäckle, O., Beyermann, M., Krause, E. & Kaupp, U.B. (2012) "Temporal
sampling, resetting, and adaptation orchestrate gradient sensing in sperm"
J. Cell Biol. 198, 1075-1091
Kaupp, U.B. (2012) "100 years of sperm chemotaxis" J. Gen.
Physiol.
140, 583-586
Kusch, J., Thon, S., Schulz, E., Biskup, C., Nache, V., Zimmer, T., Seifert, R., Schwede, F. &
Benndorf, K. (2012)
"How subunits cooperate in cAMP-induces activation of
homotetrameric HCN2 channels"
Nature Chem. Biol. 8, 162-169
Nache, V., Zimmer, T., Wongsamitkul, N., Schmauder, R., Kusch, J., Reinhardt, L., Bönigk, W., Seifert, R., Biskup,
C., Schwede, F. & Benndorf, K. (2012)
"Differential regulation by cyclic nucleotides
of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels"
Sci. Signal. 5,
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Strünker, T. (2012) "A unique K+-selective ion channel activated by a single cGMP molecule
controls chemotaxis of sea urchin sperm" In: Morisawa, M. (ed.):
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Cukkemane, A., Seifert, R. & Kaupp, U.B. (2011) "Cooperative and uncooperative
cyclic-nucleotide-gated ion channels"
Trends Biochem. Sci. 36, 55-64
Elgeti, J., Kaupp, U.B. & Gompper, G. "Response to
comment on article: hydrodynamics of sperm cells near surfaces"
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100, 2321-2324
Friedrich, B.M. & Kaupp, U.B. (2011) "Eine schwimmende
Sinneszelle"
Phys. in unserer Zeit 42, 196-200
Harzheim, D., Roderick, H.L. & Bootman, M.D. (2011) "Intracellular
calcium signaling"
In: Bradshaw, R.A. & Dennis, E.A. (eds.): Functioning of transmembrane receptors in cell
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Schünke, S., Stoldt, M., Lecher, J., Kaupp, U.B. & Willbold, D. (2011) "Structural
insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1
channel"
Proc. Natl. Acad. Sci. USA 108, 6121-6126
Strünker, T., Goodwin, N., Brenker, C., Kashikar, N.D., Weyand, I., Seifert, R. & Kaupp, U.B. (2011) "The CatSper
channel mediates progesterone-induced Ca
2+ influx in human sperm" Nature 471, 382-386
Elgeti, J., Kaupp, U.B. & Gompper, G. (2010) "Hydrodynamics of sperm cells near
surfaces"
Biophys. J. 99, 1018-1026
Fried, H.U., Kaupp, U.B. & Müller, F. (2010) "Hyperpolarization-activated and cyclic
nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice"
Cell Tissue Res. 339, 463-479
Georgiev, P., Okkenhaug, H., Drews, A., Wright, D., Lambert, S., Flick, M., Carta, V., Martel, C., Oberwinkler, J. &
Raghu, P. (2010)
"TRPM
channels mediate zinc homeostasis and cellular growth during Drosophila larval development"
Cell
Metab.
12, 386-397
Harzheim, D., Talasila, A., Movassagh, M., Foo, R.S., Figg, N., Bootman, M.D. & Roderick, H.L. (2010) "Elevated
InsP
3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events
in hypertrophic cardiac myocytes"
Channels (Austin) 4, 67-71
Kaupp, U.B. (2010) "Olfactory signalling in vertebrates and insects:
differences and commonalities"
Nat. Rev. Neurosci. 11, 188-200
Schünke, S., Lecher, J., Stoldt, M., Kaupp, U.B. & Willbold, D. (2010) "Resonance
assignments of the nucleotide-free wildtype MloK1 cyclic nucleotide-binding domain"
Biomol. NMR Assign. 4, 147-150
Smyrnias, I., Mair, W., Harzheim, D., Walker, S.A., Roderick, H.L. & Bootman, M.D. (2010) "Comparison of the
T-tubule system in adult rat ventricular and atrial myocytes, and its role in excitation-contraction coupling and
inotropic stimulation"
Cell Calcium 47, 210-223
Bönigk, W., Loogen, A., Seifert, R., Kashikar, N., Klemm, C., Krause, E., Hagen, V., Kremmer, E.,
Strünker, T. & Kaupp, U.B. (2009)
"An atypical CNG channel activated by a single cGMP
molecule controls sperm chemotaxis"
Sci. Signal. 2, ra68
Fleissner, M.R., Brustad, E.M., Kálai, T., Altenbach, C., Cascio, D., Peters, F.B., Hideg, K.,
Peuker, S., Schultz, P.G. & Hubbell, W.L. (2009)
"Site-directed spin
labeling of a genetically encoded unnatural amino acid"
Proc. Natl. Acad. Sci. USA 106, 21637-21642
Harzheim, D., Movassagh, M., Foo, R.S., Ritter, O., Tashfeen, A., Conway, S.J., Bootman, M.D. &
Roderick, H.L. (2009)
"Increased InsP3Rs in the junctional sarcoplasmic reticulum
augment Ca
2+ transients and arrhythmias associated with cardiac hypertrophy" Proc. Natl.
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USA 106, 11406-11411
Kilic, F., Kashikar, N.D., Schmidt, R., Alvarez, L., Dai, L., Weyand, I., Wiesner, B., Goodwin, N.,
Hagen, V. & Kaupp, U.B. (2009)
"Caged progesterone: a new tool for studying rapid
nongenomic actions of progesterone"
J. Am. Chem. Soc. 131, 4027-4030
Schünke, S., Stoldt, M., Novak, K., Kaupp, U.B. & Willbold, D. (2009) "Solution
structure of the Mesorhizobium loti K1 channel cyclic nucleotide-binding domain in complex with cAMP"
EMBO
Rep.
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Harzheim, D., Seifert, R., Pfeiffer, K.H., Fabritz, L., Kremmer, E., Buch, T., Waisman, A.,
Kirchhof, P. & Kaupp, U.B. (2008)
"Cardiac pacemaker function of HCN4 channels is
confined to embryonic development and requires cyclic AMP"
EMBO J. 27, 692-703
Kaupp, U.B., Kashikar, N. & Weyand, I. (2008) "Mechanisms
of sperm chemotaxis"
Ann. Rev. Physiol. 70, 93-117
Knop, G.C., Seeliger, M.W., Thiel, F., Mataruga, A., Kaupp, U.B., Friedburg, C., Tanimoto, N. &
Müller, F. (2008)
"Light
responses in the mouse retina are prolonged upon targeted deletion of the HCN1 channel gene"
Eur. J.
Neurosci.
28, 2221-2230
Löer, B. & Hoch, M. (2008) "Wech proteins: roles in
integrin functions and beyond"
Cell Adh. Migr. 2, 177-179