Publikationen

2021

Schmitz, A., Weber, A., Mehtap, B., Breuers, S., Fieberg, V., Famulok, M., and Mayer, G. (2021). A SARS-CoV-2 spike binding DNA aptamer that inhibits pseudovirus infection in vitro by an RBD independent mechanism. Angew Chem Int Ed Engl 60, 10279-10285. Link to MPG publication repository PuRe

2020

Valero, J. and Famulok, M. (2020). Regeneration of burnt bridges on a DNA catenane walker. Angew Chem Int Ed 59, 16366-16370. Link to MPG publication repository PuRe

Ma, Y., Centola, M., Keppner, D., and Famulok, M. (2020). Interlocked DNA nanojoints for reversible thermal sensing. Angew Chem Int Ed 59, 12455-12459. Link to MPG publication repository PuRe

Hornung, T., O’Neill, H.A., Logie, S.C., Fowler, K.M., Duncan, J.E., Rosenow, M., Bondre, A.S., Tinder, T., Maher, V., Zarkovic, J., Zhong, Z., Richards, M.N., Wei, X., Miglarese, M.R., Mayer, G., Famulok, M., and Spetzler, D. (2020). ADAPT identifies an ESCRT complex composition that discriminates VCaP from LNCaP prostate cancer cell exosomes. Nucleic Acids Res 48, 4013-4027. Link to MPG publication repository PuRe

Viegas, A., Yin, D.M., Borggraefe, J., Viennet, T., Falke, M., Schmitz, A., Famulok, M., and Etzkorn, M. (2020). Molecular architecture of a network of potential intracellular EGFR modulators: ARNO, CaM, phospholipids, and the juxtamembrane segment. Structure 28, 54-62. Link to MPG publication repository PuRe

2019

Škugor, M., Valero, J., Murayama, K., Centola, M., Asanuma, H., and Famulok, M. (2019). Orthogonally photocontrolled non-autonomous DNA walker. Angew Chem Int Ed 58, 6948-6951. Link to MPG publication repository PuRe

Tonapi, S.S., Pannu, V., Duncan, J.E., Rosenow, M., Helmstetter, A., Magee, D., Zhang, Q., Tinder, T.T., Richards, M., Halbert D.D., Famulok, M., Spetzler, D., Miglarese, M.R., O'Neill, H.A., and Mayer, G. (2019). Translocation of a cell surface spliceosomal complex induces alternative splicing events and lymphoma cell necrosis. Cell Chem Biol 26, 756-764. Link to MPG publication repository PuRe

2018

Haydell, M.W., Centola, M., Adam, V., Valero, J., and Famulok M. (2018). Temporal and Reversible Control of a DNAzyme by Orthogonal Photoswitching. J Am Chem Soc 140, 16868-16872. Link to MPG publication repository PuRe

Kerzhner M., Matsuoka H., Wuebben C., Famulok M., and Schiemann O. (2018). High yield spin labeling of long RNAs for EPR spectroscopy. Biochemistry 57, 2923-2931. Link to MPG publication repository PuRe

Valero J., Pal N., Dhakal S., Walter N.G., and Famulok M. (2018). A bio-hybrid DNA rotor-stator nanoengine that moves along predefined tracks. Nat Nanotechnol 13, 496-503.Link to MPG publication repository PuRe

Domenyuk V., Gatalica Z., Santhanam R., Wei X., Stark A., Kennedy P., Toussaint B., Levenberg S., Wang J., Xiao N., Greil R., Rinnerthaler G., Gampenrieder S.P., Heimberger A.B., Berry D.A., Barker A., Quackenbush J., Marshall J.L., Poste G., Vacirca J.L., Vidal G.A., Schwartzberg L.S., Halbert D.D., Voss A., Magee D., Miglarese M.R., Famulok M., Mayer G., and Spetzler D. (2018). Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes. Nat Commun 9, 1219. Link to MPG publication repository PuRe

Adam V., Prusty D.K., Centola M., Škugor M., Hannam J.S., Valero J., Klöckner B., and Famulok M. (2018). Expanding the toolbox of photoswitches for DNA nanotechnology using arylazopyrazoles. Chemistry 24, 1062-1066. Link to MPG publication repository PuRe

Prusty D.K., Adam V., Zadegan R.M., Irsen S, and Famulok M. (2018). Supramolecular aptamer nano-constructs for receptor-mediated targeting and light triggered release of chemotherapeutics into cancer cells. Nat Commun 9, 535. Link to MPG publicationi repository PuRe

Yin, D.M., Hammler, D., Peter, M.F., Marx, A., Schmitz, A., and Hagelueken, G. (2018). Inhibitor-directed spin labelling - a high precision and minimally invasive technique to study the conformation of proteins in solution. Chem Eur J 24, 6665 - 6671. Link to MPG publication repository PuRe

2017

Yin, D.M., Hannam, J.S., Schmitz, A., Schiemann, O., Hagelueken, G., and Famulok, M. (2017). Studying the conformation of a receptor tyrosine kinase in solution by inhibitor-based spin labeling. Angew Chem Int Ed Engl 56, 8417–8421. Link to MPG publication repository PuRe


Domenyuk, V., Zhong, Z., Stark, A., Xiao, N., O'Neill, H.A., Wei, X., Wang, J., Tinder, T.T., Tonapi, S., Duncan, J., Hornung, T., Hunter, A., Miglarese, M.R., Schorr, J., Halbert, D.D., Quackenbusch, J., Poste, G., Berry, D.A., Mayer, G., Famulok, M., and Spetzler, D. (2017). Plasma exosome profiling of cancer patients by a next generation systems biology approach. Sci Rep 7, 42741. Link to MPG publication repository PuRe


2016

Kerzhner, M., Abdullin, D., Wiecek, J., Matsuoka, H., Hagelueken, G., Schiermann, O., and Famulok, M. (2016).Post-synthetic spin-labeling of RNA through click chemistry for PELDOR measurements. Eur J Chem 22, 12113 - 12121. Link to MPG publication repository PuRe


Valero, J., Lohmann, F., Keppner, D., and Famulok, M. (2016). Single-stranded tile stoppers for interlocked DNA architectures. ChemBioChem 17, 1146-1149. Link to MPG publication repository PuRe

Weigandt, J., Chung, C.-L., Jester, S. S., and Famulok, M. (2016). Daisy chain rotaxanes made from interlocked DNA nanostructures. Angew Chem Int Ed Engl 55, 5512-5516. Link to MPG publication repository PuRe

Lentz, C.S., Sattler, J.M., Fendler, M., Gottwalt, S., Halls, V.S., Strassel, S., Arriens, S., Hannam, J.S., Specht, S., Famulok, M., Mueller, A.-K., Hoerauf, A., and Pfarr, K. (2015). In vitro activity of wALADin benzimidazoles against different life cycle stages of plasmodium parasites. Antimicrob Agents Chemother 59, 654 - 658. Link to MPG publication repository PuRe



2015

Lu, C.-H., Cecconello, A., Oi, X.-J., Wu, N., Jester, S.-S., Famulok, M., Matthies, M., Schmidt, T.-L., and Willner, I. (2015). Switchable reconfiguration of a seven-ring interlocked DNA catenane nanostructure. Nano Lett 15, 7133 – 7137. Link to MPG publication repository PuRe

Zhai, J., Zhang, L., Mojsilovic-Petrovic, J., Jian, X., Thomas, J., Homma, K., Schmitz, A., Famulok, M., Ichijo, H., Randazzo, P. A., and Kalb, R.G. (2015). Inhibition of cytohesins protects against genetic models of motor neuron disease. J Neurosci 35, 9088 - 9105. Link to MPG publication repository PuRe



2014

Famulok, M. and Mayer, G. (2014). Aptamers and SELEX in chemistry & biology. Chem Biol 21, 1055 - 1058. Link to MPG publication repository PuRe

Jester, S.S. and Famulok, M. (2014). Mechanically interlocked DNA nanostructures for functional devices. Acc Chem Res 47, 1700 - 1709. Link to MPG publication repository PuRe

Lentz, C.S., Halls, V.S., Hannam, J.S., Strassel, S., Lawrence, S.H., Jaffe, E.K., Famulok, M., Hoerauf, A., and Pfarr, K.M. (2014). wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs. J Med Chem 57, 2498 - 2510. Link to MPG publication repository PuRe

Li, T., Lohmann, F. and Famulok, M. (2014). Interlocked DNA nanostructures controlled by a reversible logic circuit. Nat Commun 5, 4940. Link to MPG publication repository PuRe

Lohmann, F., Valero, J., and Famulok, M. (2014). A novel family of structurally stable double stranded DNA catenanes. Chem Commun (Camb) 50, 6091 - 6093. Link to MPG publication repository PuRe

Lohmann, F., Weigandt, J., Valero, J., and Famulok, M. (2014). Logic gating by macrocycle displacement using a double-stranded DNA 3 rotaxane shuttle. Angew Chem Int Ed Engl 53, 10372 - 10376. Link to MPG publication repository PuRe

Lu, C.H., Qi, X.J., Cecconello, A., Jester, S.S., Famulok, M., and Willner, I. (2014). Switchable reconfiguration of an interlocked DNA olympiadane nanostructure. Angew Chem Int Ed Engl 53, 7499 - 7503. Link to MPG publication repository PuRe

Ackermann, D. and Famulok, M. (2013). Pseudo-complementary PNA actuators as reversible switches in dynamic DNA nanotechnology. Nucleic Acids Res 41, 4729 - 4739. Link to MPG publication repository PuRe


2013

Hussein, M., Bettio, M., Schmitz, A., Hannam, J.S., Theis, J., Mayer, G., Dosa, S., Gütschow, M., and Famulok, M. (2013). Cyplecksins are covalent inhibitors of the pleckstrin homology domain of cytohesin. Angew Chem Int Ed Engl 52, 9529 - 9533. Link to MPG publication repository PuRe

Lentz, C.S., Halls, V., Hannam, J.S., Niebel, B., Strübing, U., Mayer, G., Hoerauf, A., Famulok, M., and Pfarr, K.M. (2013) A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro. Chem Biol 20, 177 - 187. Link to MPG publication repository PuRe

Lentz, C.S., Stumpfe, D., Bajorath, J., Famulok, M., Hoerauf, A., and Pfarr, K. M (2015). New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria. Bioorg Med Chem Lett 23, 5558 - 5562. Link to MPG publication repository PuRe

Li, T. and Famulok, M. (2013). I-motif-programmed functionalization of DNA nanocircles. J Am Chem Soc 135, 1593 - 1599. Link to MPG publication repository PuRe

Niebel, B., Wosnitza, C.I., and Famulok, M. (2013). RNA-aptamers that modulate the RhoGEF activity of Tiam1. Bioorg Med Chem 21, 6239 - 6246. Link to MPG publication repository PuRe


2012

Ackermann, D., Jester, S.S., and Famulok, M. (2012). Design strategy for DNA rotaxanes with a mechanically reinforced PX100 axle. Angew Chem Int Ed Engl 51, 6771 - 6775 Link to MPG publication repository PuRe

Albertoni, B., Hannam, J.S., Ackermann, D., Schmitz, A., and Famulok, M. (2012). A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe. Chem Commun (Camb) 48, 1272 - 1274. Link to MPG publication repository PuRe

Bill, A., Schmitz, A., König, K., Heukamp, L.C., Hannam, J. S., and Famulok, M. (2012). Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells. Plos One 7, e41179. Link to MPG publication repository PuRe

Hons, M., Niebel, B., Karnowski, N., Weiche, B., and Famulok, M. (2012). Pan-selective aptamers for the family of small GTPases. Chembiochem 13, 1433-1437. Link to MPG publication repository PuRe

Li, J., Malaby, A.W., Famulok, M., Sabe, H., Lambright, D.G., and Hsu, V.W. (2012). Grp1 plays a key role in linking insulin signaling to glut4 recycling. Dev Cell 22, 1286-1298. Link to MPG publication repository PuRe

Li, T., Ackermann, D., Hall, A.M., and Famulok, M. (2012). Input-dependent induction of oligonucleotide structural motifs for performing molecular logic. J Am Chem Soc 134, 3508-3516. Link to MPG publication repository PuRe

Lohmann, F., Ackermann, D., and Famulok, M. (2012). Reversible light switch for macrocycle mobility in a DNA rotaxane. J Am Chem Soc 134, 11884-11887. Link to MPG publication repository PuRe

Miao, B., Skidan, I., Yang, J., You, Z., Fu, X., Famulok, M., Schaffhausen, B., Torchilin, V., Yuan, J., and Degterev, A. (2012). Inhibition of cell migration by PITENINs: the role of ARF6. Oncogene 31, 4317 - 4332. Link to MPG publication repository PuRe

Rohrbach, F., Karadeniz, H., Erdem, A., Famulok, M., and Mayer, G. (2012). Label-free impedimetric aptasensor for lysozyme detection based on carbon nanotube-modified screen-printed electrodes. Anal biochem 421, 454 - 459. Link to MPG publication repository PuRe

Vinkenborg, J.L., Mayer, G., and Famulok, M. (2012). Aptamer-based affinity labeling of proteins. Angew Chem Int Ed Engl 51, 9176-9180. Link to MPG publication repository PuRe

Beyer, M., Thabet, Y., Müller, R.U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S.L., Krebs, W., Schönfeld, E.A., Böttcher, J., Golovina, T., Mayer, C.T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., Hippen, K.L., Blazar, B.R., Balderas, R., Quast, T., Waha, A., Mayer, G., Famulok, M., Knolle, P.A., Wickenhauser, C., Kolanus, W., Schermer, B., Bluestone, J.A., Barry, S.C., Sparwasser, T., Riley, J.L., and Schultze, J.L. (2011). Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol 12, 898-907. Link to MPG publication repository PuRe


2011

Bill, A., Blockus, H., Stumpfe, D., Bajorath, J., Schmitz, A., and Famulok, M. (2011). A homogeneous fluorescence resonance energy transfer system for monitoring the activation of a protein switch in real time. J Am Chem Soc 133, 8372 - 8379. Link to MPG publication repository PuRe

Famulok, M., and Mayer, G. (2011). Aptamer modules as sensors and detectors. Acc Chem Res 44, 1349-1358. Link to MPG publication repository PuRe

Niebel, B., Weiche, B., Mueller, A.L., Li, D.Y., Karnowski, N., and Famulok, M. (2011). A luminescent oxygen channeling biosensor that measures small GTPase activation. Chem Commun 47, 7521-7523. Link to MPG publication repository PuRe

Vinkenborg, J.L., Karnowski, N., and Famulok, M. (2011). Aptamers for allosteric regulation. Nat Chem Biol 7, 519-527. Link to MPG publication repository PuRe


2010

Ackermann, D., Rasched, G., Verma, S., Schmidt, T.L., Heckel, A., and Famulok, M. (2010). Assembly of dsDNA nanocircles into dimeric and oligomeric aggregates. Chem Commun (Camb) 46, 4154-4156. Link to MPG publication repository PuRe

Ackermann, D., Schmidt, T.L., Hannam, J.S., Purohit, C.S., Heckel, A., and Famulok, M. (2010). A double-stranded DNA rotaxane. Nat Nanotechn 5, 436-442. Link to MPG publication repository PuRe

Lünse, C.E., Michlewski, G., Hopp, C.S., Rentmeister, A., Caceres, J.F., Famulok, M., and Mayer, G. (2010). An aptamer targeting the apical-loop domain modulates pri-miRNA processing. Angew Chem Int Ed Engl 49, 4674-4677. Link to MPG publication repository PuRe

Mayer, G., Ahmed, M.S., Dolf, A., Endl, E., Knolle, P.A., and Famulok, M. (2010). Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures. Nat Protoc 5, 1993-2004. Link to MPG publication repository PuRe

Niebel, B., Lentz, C., Pofahl, M., Mayer, G., Hoerauf, A., Pfarr, K.M., and Famulok, M. (2010). ADLOC: an aptamer-displacement assay based on luminescent oxygen channeling. Chemistry 16, 11100-11107. Link to MPG publication repository PuRe

Stumpfe, D., Bill, A., Novak, N., Loch, G., Blockus, H., Geppert, H., Becker, T., Schmitz, A., Hoch, M., Kolanus, W., Famulok, M., and Bajorath, J. (2010). Targeting multifunctional proteins by virtual screening: structurally diverse cytohesin inhibitors with differentiated biological functions. ACS Chem Biol 5, 839-849. Link to MPG publication repository PuRe


2009

Klotz, L., Burgdorf, S., Dani, I., Saijo, K., Flossdorf, J., Hucke, S., Alferink, J., Nowak, N., Beyer, M., Mayer, G., Langhans, B., Klockgether, T., Waisman, A., Eberl, G., Schultze, J., Famulok, M., Kolanus, W., Glass, C., Kurts, C., and Knolle, P.A. (2009). The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med 206, 2079-2089. Link to MPG publication repository PuRe

Jones, C.A., Nishiya, N., London, N.R., Zhu, W., Sorensen, L.K., Chan, A., Lim, C.J., Chen, H., Zhang, Q., Schultz, P.G., Hayallah, A.M., Thomas, R.K., Famulok, M., Zhang, K., Ginsberg, H.H., and Li, D.Y. (2009). Slit2-Robo4 signaling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol 11, 1325-1331. Link to MPG publication repository PuRe

Gronewold, T.M., Baumgartner, A., Hierer, J., Sierra, S., Blind, M., Schäfer, F., Blümer, J., Tillmann, T., Kiwitz, A., Kaiser, R., Zabe-Kühn, M., Quandt, E., and Famulok, M. (2009). Kinetic binding analysis of aptamers targeting HIV-1 proteins by a combination of a microbalance array and mass spectrometry (MAMS). J Proteome Res 8, 3568-3577. Link to MPG publication repository PuRe

Beyer, M., Karbach, J., Mallmann, M.R., Zander, T., Eggle, D., Classen, S., Debey-Pascher, S., Famulok, M., Jäger, E., and Schultze, J.L. (2009). Cancer vaccine enhanced, non-tumor-reactive CD8(+) T cells exhibit a distinct molecular program associated with division arrest anergy. Cancer Res 69, 4346-4354. Link to MPG publication repository PuRe

Erdem, A., Karadeniz, H., Mayer, G., Famulok, M., and Caliskan, A. (2009). Electrochemical sensing of aptamer-protein interactions using magnetic particle assay and single-use sensor technology. Electroanalysis 21, 1278-1284. Link to MPG publication repository PuRe

Famulok, M. (2009). Exploring chemical space with aptamers. J Med Chem 52, 6951-6957. Link to MPG publication repository PuRe


2008

Bi, X., Schmitz, A., Hayallah, A.M., Song, J.N., and Famulok, M. (2008). Affinity-based labeling of cytohesins with a bifunctional SecinH3 photoaffinity probe. Angew Chem Int Ed 47, 9565-9568. Link to MPG publication repository PuRe

Fusz, S., Srivatsan, S.G., Ackermann, D., and Famulok, M. (2008). Photocleavable initiator nucleotide substrates for an aldolase ribozyme. J Org Chem 73, 5069-5077. Link to MPG publication repository PuRe

Hafner, M., Vianini, E., Albertoni, B., Marchetti, L., Grüne, I., Gloeckner, C., and Famulok, M. (2008). Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization. Nat Prot 3, 579-587. Link to MPG publication repository PuRe

Heckel, A., and Famulok, M. (2008). Building objects from nucleic acids for a nanometer world. Biochimie 90, 1096-1107. Link to MPG publication repository PuRe

Mayer, G., Ackermann, D., Kuhn, N., and Famulok, M. (2008). Construction of DNA architectures with RNA hairpins. Angew Chem Int Ed 47, 971-973. Link to MPG publication repository PuRe

Raddatz, M.S., Dolf, A., Endl, E., Knolle, P., Famulok, M., and Mayer, G. (2008). Enrichment of cell-targeting and population-specific aptamers by fluorescence-activated cell sorting. Angew Chem Int Ed 47, 5190-5193. Link to MPG publication repository PuRe

Rasched, G., Ackermann, D., Schmidt, T.L., Broekmann, P., Heckel, A., and Famulok, M. (2008). DNA minicircles with gaps for versatile functionalization. Angew Chem Int Ed 47, 967-970. Link to MPG publication repository PuRe

Rentmeister, A., Mayer, G., Kuhn, N., and Famulok, M. (2008). Secondary structures and functional requirements for thiM riboswitches from Desulfovibrio vulgaris, Erwinia carotovora and Rhodobacter spheroides. Biol Chem 389, 127-134. Link to MPG publication repository PuRe

2021

Schmitz, A., Weber, A., Mehtap, B., Breuers, S., Fieberg, V., Famulok, M., and Mayer, G. (2021). A SARS-CoV-2 spike binding DNA aptamer that inhibits pseudovirus infection in vitro by an RBD independent mechanism. Angew Chem Int Ed Engl 60, 10279-10285. Link to MPG publication repository PuRe

2020

Valero, J. and Famulok, M. (2020). Regeneration of burnt bridges on a DNA catenane walker. Angew Chem Int Ed 59, 16366-16370. Link to MPG publication repository PuRe

Ma, Y., Centola, M., Keppner, D., and Famulok, M. (2020). Interlocked DNA nanojoints for reversible thermal sensing. Angew Chem Int Ed 59, 12455-12459. Link to MPG publication repository PuRe

Hornung, T., O’Neill, H.A., Logie, S.C., Fowler, K.M., Duncan, J.E., Rosenow, M., Bondre, A.S., Tinder, T., Maher, V., Zarkovic, J., Zhong, Z., Richards, M.N., Wei, X., Miglarese, M.R., Mayer, G., Famulok, M., and Spetzler, D. (2020). ADAPT identifies an ESCRT complex composition that discriminates VCaP from LNCaP prostate cancer cell exosomes. Nucleic Acids Res 48, 4013-4027. Link to MPG publication repository PuRe

Viegas, A., Yin, D.M., Borggraefe, J., Viennet, T., Falke, M., Schmitz, A., Famulok, M., and Etzkorn, M. (2020). Molecular architecture of a network of potential intracellular EGFR modulators: ARNO, CaM, phospholipids, and the juxtamembrane segment. Structure 28, 54-62 e5. Link to MPG publication repository PuRe

2019

Škugor, M., Valero, J., Murayama, K., Centola, M., Asanuma, H., and Famulok, M. (2019). Orthogonally photocontrolled non-autonomous DNA walker. Angew Chem Int Ed 58, 6948-6951. Link to MPG publication repository PuRe

Tonapi, S.S., Pannu, V., Duncan, J.E., Rosenow, M., Helmstetter, A., Magee, D., Zhang, Q., Tinder, T.T., Richards, M., Halbert D.D., Famulok, M., Spetzler, D., Miglarese, M.R., O'Neill, H.A., and Mayer, G. (2019). Translocation of a cell surface spliceosomal complex induces alternative splicing events and lymphoma cell necrosis. Cell Chem Biol 26, 756-764.e6. Link to MPG publication repository PuRe

2018

Haydell, M.W., Centola, M., Adam, V., Valero, J., and Famulok M. (2018). Temporal and Reversible Control of a DNAzyme by Orthogonal Photoswitching. J Am Chem Soc 140, 16868-16872. Link to MPG publication repository PuRe

Kerzhner M., Matsuoka H., Wuebben C., Famulok M., and Schiemann O. (2018). High yield spin labeling of long RNAs for EPR spectroscopy. Biochemistry 57, 2923-2931. Link to MPG publication repository PuRe

Valero J., Pal N., Dhakal S., Walter N.G., and Famulok M. (2018). A bio-hybrid DNA rotor-stator nanoengine that moves along predefined tracks. Nat Nanotechnol 13, 496-503.Link to MPG publication repository PuRe

Domenyuk V., Gatalica Z., Santhanam R., Wei X., Stark A., Kennedy P., Toussaint B., Levenberg S., Wang J., Xiao N., Greil R., Rinnerthaler G., Gampenrieder S.P., Heimberger A.B., Berry D.A., Barker A., Quackenbush J., Marshall J.L., Poste G., Vacirca J.L., Vidal G.A., Schwartzberg L.S., Halbert D.D., Voss A., Magee D., Miglarese M.R., Famulok M., Mayer G., and Spetzler D. (2018). Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes. Nat Commun 9, 1219. Link to MPG publication repository PuRe

Adam V., Prusty D.K., Centola M., Škugor M., Hannam J.S., Valero J., Klöckner B., and Famulok M. (2018). Expanding the toolbox of photoswitches for DNA nanotechnology using arylazopyrazoles. Chemistry 24, 1062-1066. Link to MPG publication repository PuRe

Prusty D.K., Adam V., Zadegan R.M., Irsen S, and Famulok M. (2018). Supramolecular aptamer nano-constructs for receptor-mediated targeting and light triggered release of chemotherapeutics into cancer cells. Nat Commun 9, 535. Link to MPG publicationi repository PuRe

Yin, D.M., Hammler, D., Peter, M.F., Marx, A., Schmitz, A., and Hagelueken, G. (2018). Inhibitor-directed spin labelling - a high precision and minimally invasive technique to study the conformation of proteins in solution. Chem Eur J 24, 6665 - 6671. Link to MPG publication repository PuRe

2017

Yin, D.M., Hannam, J.S., Schmitz, A., Schiemann, O., Hagelueken, G. & Famulok, M. (2017). Studying the conformation of a receptor tyrosine kinase in solution by inhibitor-based spin labeling. Angew. Chem. Int. Ed. Engl. 56, 8417–8421. Link to MPG publication repository PuRe


Domenyuk, V., Zhong, Z., Stark, A., Xiao, N., O'Neill, H.A., Wei, X., Wang, J., Tinder, T.T., Tonapi, S., Duncan, J., Hornung, T., Hunter, A., Miglarese, M.R., Schorr, J., Halbert, D.D., Quackenbusch, J., Poste, G., Berry, D.A., Mayer, G., Famulok, M., and Spetzler, D. (2017). Plasma exosome profiling of cancer patients by a next generation systems biology approach. Sci. Rep. 7, 42741. Link to MPG publication repository PuRe


2016

Kerzhner, M., Abdullin, D., Wiecek, J., Matsuoka, H., Hagelueken, G., Schiermann, O., and Famulok, M. (2016).Post-synthetic spin-labeling of RNA through click chemistry for PELDOR measurements" Eur. J. Chem. 22, 12113 - 12121.


Valero, J., Lohmann, F., Keppner, D., and Famulok, M. (2016). Single-stranded tile stoppers for interlocked DNA architectures. ChemBioChem 17, 1146-1149. Link to MPG publication repository PuRe

Weigandt, J., Chung, C.-L., Jester, S. S., and Famulok, M. (2016). Daisy chain rotaxanes made from interlocked DNA nanostructures. Angew. Chem. Int. Ed. Engl. 55, 5512-5516. Link to MPG publication repository PuRe

Lentz, C.S., Sattler, J.M., Fendler, M., Gottwalt, S., Halls, V.S., Strassel, S., Arriens, S., Hannam, J.S., Specht, S., Famulok, M., Mueller, A.-K., Hoerauf, A., and Pfarr, K. (2015). In vitro activity of wALADin benzimidazoles against different life cycle stages of plasmodium parasites. Antimicrob. Agents Chemother.59, 654 - 658. Link to MPG publication repository PuRe



2015

Lu, C.-H., Cecconello, A., Oi, X.-J., Wu, N., Jester, S.-S., Famulok, M., Matthies, M., Schmidt, T.-L., and Willner, I. (2015). Switchable reconfiguration of a seven-ring interlocked DNA catenane nanostructure. Nano Lett. 15, 7133 – 7137. Link to MPG publication repository PuRe

Zhai, J., Zhang, L., Mojsilovic-Petrovic, J., Jian, X., Thomas, J., Homma, K., Schmitz, A., Famulok, M., Ichijo, H., Randazzo, P. A., and Kalb, R.G. (2015). Inhibition of cytohesins protects against genetic models of motor neuron disease. J. Neurosci. 35, 9088 - 9105. Link to MPG publication repository PuRe



2014

Famulok, M. and Mayer, G. (2014). Aptamers and SELEX in chemistry & biology. Chem. Biol. 21, 1055 - 1058. Link to MPG publication repository PuRe

Jester, S.S. and Famulok, M. (2014). Mechanically interlocked DNA nanostructures for functional devices. Acc. Chem. Res. 47, 1700 - 1709. Link to MPG publication repository PuRe

Lentz, C.S., Halls, V.S., Hannam, J.S., Strassel, S., Lawrence, S.H., Jaffe, E.K., Famulok, M., Hoerauf, A., and Pfarr, K.M. (2014). wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs. J. Med. Chem. 57, 2498 - 2510. Link to MPG publication repository PuRe

Li, T., Lohmann, F. and Famulok, M. (2014). Interlocked DNA nanostructures controlled by a reversible logic circuit. Nat. Commun. 5, 4940. Link to MPG publication repository PuRe

Lohmann, F., Valero, J., and Famulok, M. (2014). A novel family of structurally stable double stranded DNA catenanes. Chem. Commun. (Camb.) 50, 6091 - 6093. Link to MPG publication repository PuRe

Lohmann, F., Weigandt, J., Valero, J., and Famulok, M. (2014). Logic gating by macrocycle displacement using a double-stranded DNA 3 rotaxane shuttle. Angew. Chem. Int. Ed. Engl. 53, 10372 - 10376. Link to MPG publication repository PuRe

Lu, C.H., Qi, X.J., Cecconello, A., Jester, S.S., Famulok, M., and Willner, I. (2014). Switchable reconfiguration of an interlocked DNA olympiadane nanostructure. Angew. Chem. Int. Ed. Engl. 53, 7499 - 7503. Link to MPG publication repository PuRe

Ackermann, D. and Famulok, M. (2013). Pseudo-complementary PNA actuators as reversible switches in dynamic DNA nanotechnology. Nucleic Acids Res. 41, 4729 - 4739. Link to MPG publication repository PuRe


2013

Hussein, M., Bettio, M., Schmitz, A., Hannam, J.S., Theis, J., Mayer, G., Dosa, S., Gütschow, M., and Famulok, M. (2013). Cyplecksins are covalent inhibitors of the pleckstrin homology domain of cytohesin. Angew. Chem. Int. Ed. Engl. 52, 9529 - 9533. Link to MPG publication repository PuRe

Lentz, C.S., Halls, V., Hannam, J.S., Niebel, B., Strübing, U., Mayer, G., Hoerauf, A., Famulok, M. & Pfarr, K.M. (2013) A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro. Chem. Biol. 20, 177 - 187. Link to MPG publication repository PuRe

Lentz, C.S., Stumpfe, D., Bajorath, J., Famulok, M., Hoerauf, A., and Pfarr, K. M (2015). New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria. Bioorg. Med. Chem. Lett. 23, 5558 - 5562. Link to MPG publication repository PuRe

Li, T. and Famulok, M. (2013). I-motif-programmed functionalization of DNA nanocircles. J. Am. Chem. Soc. 135, 1593 - 1599. Link to MPG publication repository PuRe

Niebel, B., Wosnitza, C.I., and Famulok, M. (2013). RNA-aptamers that modulate the RhoGEF activity of Tiam1. Bioorg. Med. Chem. 21, 6239 - 6246. Link to MPG publication repository PuRe


2012

Ackermann, D., Jester, S.S., and Famulok, M. (2012). Design strategy for DNA rotaxanes with a mechanically reinforced PX100 axle. Angew. Chem. In.t Ed. Engl. 51, 6771 - 6775 Link to MPG publication repository PuRe

Albertoni, B., Hannam, J.S., Ackermann, D., Schmitz, A., and Famulok, M. (2012). A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe. Chem. Commun. (Camb.) 48, 1272 - 1274. Link to MPG publication repository PuRe

Bill, A., Schmitz, A., König, K., Heukamp, L.C., Hannam, J. S., and Famulok, M. (2012). Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells. Plos One 7, e41179. Link to MPG publication repository PuRe

Hons, M., Niebel, B., Karnowski, N., Weiche, B., and Famulok, M. (2012). Pan-selective aptamers for the family of small GTPases. Chembiochem 13, 1433 - 1437. Link to MPG publication repository PuRe

Li, J., Malaby, A.W., Famulok, M., Sabe, H., Lambright, D.G., and Hsu, V.W. (2012). Grp1 plays a key role in linking insulin signaling to glut4 recycling. Dev. Cell 22, 1286 - 1298. Link to MPG publication repository PuRe

Li, T., Ackermann, D., Hall, A.M., and Famulok, M. (2012). Input-dependent induction of oligonucleotide structural motifs for performing molecular logic. J. Am. Chem. Soc. 134, 3508 - 3516. Link to MPG publication repository PuRe

Lohmann, F., Ackermann, D., and Famulok, M. (2012). Reversible light switch for macrocycle mobility in a DNA rotaxane. J. Am. Chem. Soc. 134, 11884 - 11887. Link to MPG publication repository PuRe

Miao, B., Skidan, I., Yang, J., You, Z., Fu, X., Famulok, M., Schaffhausen, B., Torchilin, V., Yuan, J., and Degterev, A. (2012). Inhibition of cell migration by PITENINs: the role of ARF6. Oncogene 31, 4317 - 4332. Link to MPG publication repository PuRe

Rohrbach, F., Karadeniz, H., Erdem, A., Famulok, M., and Mayer, G. (2012). Label-free impedimetric aptasensor for lysozyme detection based on carbon nanotube-modified screen-printed electrodes. Analytical biochemistry 421, 454 - 459. Link to MPG publication repository PuRe

Vinkenborg, J.L., Mayer, G. & Famulok, M. (2012). Aptamer-based affinity labeling of proteins. Angew. Chem. In.t Ed. Engl. 51, 9176 - 9180. Link to MPG publication repository PuRe

Beyer, M., Thabet, Y., Müller, R.U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S.L., Krebs, W., Schönfeld, E.A., Böttcher, J., Golovina, T., Mayer, C.T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., Hippen, K.L., Blazar, B.R., Balderas, R., Quast, T., Waha, A., Mayer, G., Famulok, M., Knolle, P.A., Wickenhauser, C., Kolanus, W., Schermer, B., Bluestone, J.A., Barry, S.C., Sparwasser, T., Riley, J.L., and Schultze, J.L. (2011). Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat. Immunol. 12, 898 - 907. Link to MPG publication repository PuRe


2011

Bill, A., Blockus, H., Stumpfe, D., Bajorath, J., Schmitz, A. & Famulok, M. (2011) "A homogeneous fluorescence resonance energy transfer system for monitoring the activation of a protein switch in real time" J. Am. Chem. Soc. 133, 8372 - 8379 Link to MPG publication repository PuRe

Famulok, M. & Mayer, G. (2011) "Aptamer modules as sensors and detectors" Acc. Chem. Res. 44, 1349 - 1358 Link to MPG publication repository PuRe

Niebel, B., Weiche, B., Mueller, A.L., Li, D.Y., Karnowski, N. & Famulok, M. (2011) "A luminescent oxygen channeling biosensor that measures small GTPase activation" Chem. Commun. 47, 7521 - 7523 Link to MPG publication repository PuRe

Vinkenborg, J.L., Karnowski, N. & Famulok, M. (2011) "Aptamers for allosteric regulation" Nat. Chem. Biol. 7, 519 - 527 Link to MPG publication repository PuRe


2010

Ackermann, D., Rasched, G., Verma, S., Schmidt, T.L., Heckel, A. & Famulok, M. (2010) "Assembly of dsDNA nanocircles into dimeric and oligomeric aggregates" Chem. Commun. (Camb.) 46, 4154 - 4156 Link to MPG publication repository PuRe

Ackermann, D., Schmidt, T.L., Hannam, J.S., Purohit, C.S., Heckel, A. & Famulok, M. (2010) "A double-stranded DNA rotaxane" Nat. Nanotechn. 5, 436 - 442 Link to MPG publication repository PuRe

Lünse, C.E., Michlewski, G., Hopp, C.S., Rentmeister, A., Caceres, J.F., Famulok, M. & Mayer, G. (2010) "An aptamer targeting the apical-loop domain modulates pri-miRNA processing" Angew. Chem. Int. Ed. Engl. 49, 4674 - 4677 Link to MPG publication repository PuRe

Mayer, G., Ahmed, M.S., Dolf, A., Endl, E., Knolle, P.A. & Famulok, M. (2010) "Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures" Nat. Protoc. 5, 1993 - 2004 Link to MPG publication repository PuRe

Niebel, B., Lentz, C., Pofahl, M., Mayer, G., Hoerauf, A., Pfarr, K.M. & Famulok, M. (2010) "ADLOC: an aptamer-displacement assay based on luminescent oxygen channeling" Chemistry 16, 11100 - 11107 Link to MPG publication repository PuRe

Stumpfe, D., Bill, A., Novak, N., Loch, G., Blockus, H., Geppert, H., Becker, T., Schmitz, A., Hoch, M., Kolanus, W., Famulok, M. & Bajorath, J. (2010) "Targeting multifunctional proteins by virtual screening: structurally diverse cytohesin inhibitors with differentiated biological functions" ACS Chem. Biol. 5, 839 - 849 Link to MPG publication repository PuRe


2009

Klotz, L., Burgdorf, S., Dani, I., Saijo, K., Flossdorf, J., Hucke, S., Alferink, J., Nowak, N., Beyer, M., Mayer, G., Langhans, B., Klockgether, T., Waisman, A., Eberl, G., Schultze, J., Famulok, M., Kolanus, W., Glass, C., Kurts, C. & Knolle, P.A. (2009) "The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity" J. Exp. Med. 206, 2079-2089 Link to MPG publication repository PuRe

Jones, C.A., Nishiya, N., London, N.R., Zhu, W., Sorensen, L.K., Chan, A., Lim, C.J., Chen, H., Zhang, Q., Schultz, P.G., Hayallah, A.M., Thomas, R.K., Famulok, M., Zhang, K., Ginsberg, H.H. & Li, D.Y. (2009) "Slit2-Robo4 signaling promotes vascular stability by blocking Arf6 activity" Nat. Cell Biol. 11, 1325-1331 Link to MPG publication repository PuRe

Gronewold, T.M., Baumgartner, A., Hierer, J., Sierra, S., Blind, M., Schäfer, F., Blümer, J., Tillmann, T., Kiwitz, A., Kaiser, R., Zabe-Kühn, M., Quandt, E. & Famulok, M. (2009) "Kinetic binding analysis of aptamers targeting HIV-1 proteins by a combination of a microbalance array and mass spectrometry (MAMS)" J. Proteome Res. 8, 3568-3577 Link to MPG publication repository PuRe

Beyer, M., Karbach, J., Mallmann, M.R., Zander, T., Eggle, D., Classen, S., Debey-Pascher, S., Famulok, M., Jäger, E. & Schultze, J.L. (2009) "Cancer vaccine enhanced, non-tumor-reactive CD8(+) T cells exhibit a distinct molecular program associated with "division arrest anergy" Cancer Res. 69, 4346-4354 Link to MPG publication repository PuRe

Erdem, A., Karadeniz, H., Mayer, G., Famulok, M. & Caliskan, A. (2009) "Electrochemical sensing of aptamer-protein interactions using magnetic particle assay and single-use sensor technology" Electroanalysis 21, 1278-1284 Link to MPG publication repository PuRe

Famulok, M. (2009) "Exploring chemical space with aptamers" J. Med. Chem. 52, 6951-6957 Link to MPG publication repository PuRe


2008

Bi, X., Schmitz, A., Hayallah, A.M., Song, J.N. & Famulok, M. (2008) "Affinity-based labeling of cytohesins with a bifunctional SecinH3 photoaffinity probe" Angew. Chem. Int. Ed. 47, 9565-9568 Link to MPG publication repository PuRe

Fusz, S., Srivatsan, S.G., Ackermann, D. & Famulok, M. (2008) "Photocleavable initiator nucleotide substrates for an aldolase ribozyme" J. Org. chem. 73, 5069-5077 Link to MPG publication repository PuRe

Hafner, M., Vianini, E., Albertoni, B., Marchetti, L., Grüne, I., Gloeckner, C. & Famulok, M. (2008) "Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization" Nat. Prot. 3, 579-587 Link to MPG publication repository PuRe

Heckel, A. & Famulok, M. (2008) "Building objects from nucleic acids for a nanometer world" Biochimie 90, 1096-1107 Link to MPG publication repository PuRe

Mayer, G., Ackermann, D., Kuhn, N. & Famulok, M. (2008) "Construction of DNA architectures with RNA hairpins" Angew. Chem. Int. Ed. 47, 971-973 Link to MPG publication repository PuRe

Raddatz, M.S., Dolf, A., Endl, E., Knolle, P., Famulok, M. & Mayer, G. (2008) "Enrichment of cell-targeting and population-specific aptamers by fluorescence-activated cell sorting" Angew. Chem. Int. Ed. 47, 5190-5193 Link to MPG publication repository PuRe

Rasched, G., Ackermann, D., Schmidt, T.L., Broekmann, P., Heckel, A. & Famulok, M. (2008) "DNA minicircles with gaps for versatile functionalization" Angew. Chem. Int. Ed. 47, 967-970 Link to MPG publication repository PuRe

Rentmeister, A., Mayer, G., Kuhn, N. & Famulok, M. (2008) "Secondary structures and functional requirements for thiM riboswitches from Desulfovibrio vulgaris, Erwinia carotovora and Rhodobacter spheroides" Biol. Chem. 389, 127-134 Link to MPG publication repository PuRe