Event: Neuroscience Seminar Series
Discriminating minor changes in otherwise similar environments is essential for all mammals. This capability requires the ability to generate dissimilar neuronal representations from two overlapping input states representing two similar environments. Such an operation, termed pattern separation, has been ascribed to the hippocampal dentate gyrus in different species ranging from rodents to humans. The presentation will first address cellular and circuit mechanisms supporting pattern separation in the dentate gyrus. I will then describe a novel type of replay in the dentate gyrus that promotes the transformation of pattern-separated representations into precise memories.