In Silico Brain Sciences

Max Planck Research Group

We reconstruct neural networks and elucidate mechanistic principles of how the brain integrates sensory information.


Barth, A., Burkhalter, A., Callaway , E. M., Connors, B.W., Cauli, B., DeFelipe, J., Feldmeyer, D., Freund, T., Kawaguchi, Y., Kisvarday, Z., Kubota, Y., McBain, C., Oberlaender, M., Rossier, J., Rudy, B., Staiger, J. F., Somogyi, P., Tamas, G. & Yuste, R. (2016) "Comment on "Principles of connectivity among morphologically defined cell types in adult neocortex"" Science 353, 1108

Landau, I.D., Egger, R., Dercksen, V.J., Oberlaender, M. & Sompolinsky, H. (2016) „The Impact of structural heterogeneity on excitation-inhibition balance in cortical networks" Neuron 92 , 1106-1121

Narayanan, R.T., Egger, R., Kock, C.P.J. & Oberlaender, M. (2016) "Neuronal cell types in the neocortex" In: Rockland, K.S. (ed.): Axons and brain architecutre (Amsterdam, The Netherlands: Elsevier Academic Press), 183 - 202

Egger, R., Schmitt, A.C., Wallace, D.J., Sakmann, B., Oberlaender, M. & Kerr, J.D (2015) "Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites" Proc. Natl. Acad. Sci. USA 112, 14072 - 14077

Egger, R. & Oberlaender, M. (2015) "Cell types in the cerebral cortex: an overview from the rat vibrissal cortex" In: Toga, A.W. (ed.): Brain Mapping: an Encyclopedic Reference (Amsterdam, The Netherlands: Academic Press), 59 - 64

Haberl, M.G., Silva, S.V., Guest, J.M., Ginger, M., Ghanem, A., Mulle, C., Oberlaender, M., Conzelmann, K.-K. & Frick, A. (2015) "An anterograde rabies virus vector for high-resolution large-scale reconstruction of 3D neuron morphology" Brain Struct. Funct. 220, 1369 - 1379

Narayanan, R.T., Egger, R., Johnson, A.S., Mansvelder, H.D., Sakmann, B., De Kock, C.P.J. & Oberlaender, M. (2015) "Beyond columnar organization: cell type- and target layer-specific principles of horizontal axon projection patterns in rat vibrissal cortex" Cereb. Cortex 25, 4450 - 4468

Dercksen, V.J., Hege, H.-C. & Oberlaender, M. (2014) "The filament editor: an interactive software environment for visualization, proof-editing and analysis of 3D neuron morphology" Neuroinformatics 12, 325 - 339

Egger, R., Dercksen, V.J., De Kock, C.P.J. & Oberlaender, M. (2014) "Reverse engineering the 3D structure and sensory-evoked signal flow of rat vibrissal cortex" In: Cuntz, H. (ed.): The Computing Dendrite: form Structure to Function (New York, NY, USA: Springer), 127 – 145

Egger, R., Dercksen, V.J., Udvary, D., Hege, H.-C. & Oberlaender, M. (2014) "Generation of dense statistical connectomes from sparse morphological data" Front. Neuroanat. 8, 1 - 18

Meyer, H.S., Egger, R., Guest, J.M., Foerster, R., Reissl, S. & Oberlaender, M. (2013) "Cellular organization of cortical barrel columns is whisker-specific" Proc. Natl. Acad. Sci. USA 110, 19113 - 19118

Dercksen, V.J., Oberlaender, M., Sakmann, B. & Hege, H. C. (2012) "Interactive visualization-A Key prerequisite for reconstruction and analysis of anatomically realistic neural networks" In: Linsen, L. (ed.): Visualization in medicine and life sciences II (Berlin: Springer), 27 - 44

Egger, R., Narayanan, R.T., De Kock, C.P.J. & Oberlaender, M. (2012) "3D reconstruction and standardization of the rat vibrissal cortex for precise registration of single neuron morphology" PLoS Computational Biology 8, 1 - 18

Oberlaender, M., Ramirez, A. & Bruno, R.M. (2012) "Sensory experience restructures thalamocortical axons during adulthood" Neuron 74, 648 - 655

Oberlaender, M., De Kock, C.P.J., Bruno, R.M., Ramirez, A., Meyer, H.S., Dercksen, V.J., Helmstaedter, M. & Sakmann, B. (2012) "Cell type-specific three-dimensional structure of thalamocortical circuits in a column of rat vibrissal cortex" Cereb. Cortex 22, 2375 – 2391

Oberlaender, M., Boudewijns, Z.S.R.M., Mansvelder, H.D., Sakmann, B. & De Kock, C.P.J. (2011) "Three-dimensional axon morphologies of individual layer 5 neurons indicate cell type-specific intracortical pathways for whisker motion and touch" Proc. Natl. Acad. Sci. USA 108, 4188 - 4193

Boudewijns, Z.S.R., Kleele, T., Mansvelder, H.D., Sakmann, B., De Kock, C.P.J. & Oberlaender, M. (2011) "Semi-automated three-dimensional reconstructions of individual neurons reveal cell type-specific circuits in cortex" Commun. Integr. Biol. 4, 486 - 488

Lang, S., Dercksen, V.J., Sakmann, B. & Oberlaender, M. (2011) "Simulation of signal flow in 3D reconstructions of an anatomically realistic neural network in rat vibrissal cortex" Neural Netw. 24, 998 - 1011

Kleinfeld, D., Bharioke, A., Blinder, P., Bock, D.D., Briggman, K.L., Chklovskii, D.B., Denk, W., Helmstadter, M., Kaufhold, J.P., Lee, W.-C.A., Meyer, H.S., Micheva, K.D., Oberlaender, M., Prohaska, S., Reid, R.C., Smith, S.J., Takemura, S., Tsai, P.S. & Sackmann, B. (2011) "Large-scale automated histology in the pursuit of connectomes" J. Neurosci. 31, 16125 - 16138

Meyer, H.S., Wimmer, V.C., Oberlaender, M., De Kock, C.P.J., Sakmann, B. & Helmstaedter, M. (2010) "Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex" Cereb. Cortex 20, 2277 - 2286