In Silico Brain Sciences

Max Planck Research Group

We reconstruct neural networks and elucidate mechanistic principles of how the brain integrates sensory information.

Publications

Kornfeld, J., Benezra, S.E., Narayanan, R.T., Svara, F., Egger, R., Oberlaender, M., Denk, W. & Long, M.A. (2017) “EM connectomics reveals axonal target variation in a sequence-generating network” eLife 6, e24364

Barth, A., Burkhalter, A., Callaway , E. M., Connors, B.W., Cauli, B., DeFelipe, J., Feldmeyer, D., Freund, T., Kawaguchi, Y., Kisvarday, Z., Kubota, Y., McBain, C., Oberlaender, M., Rossier, J., Rudy, B., Staiger, J. F., Somogyi, P., Tamas, G. & Yuste, R. (2016) "Comment on "Principles of connectivity among morphologically defined cell types in adult neocortex"" Science 353, 1108

Landau, I.D., Egger, R., Dercksen, V.J., Oberlaender, M. & Sompolinsky, H. (2016) „The Impact of structural heterogeneity on excitation-inhibition balance in cortical networks" Neuron 92 , 1106-1121

Narayanan, R.T., Egger, R., Kock, C.P.J. & Oberlaender, M. (2016) "Neuronal cell types in the neocortex" In: Rockland, K.S. (ed.): Axons and brain architecutre (Amsterdam, The Netherlands: Elsevier Academic Press), 183 - 202

Egger, R., Schmitt, A.C., Wallace, D.J., Sakmann, B., Oberlaender, M. & Kerr, J.D (2015) "Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites" Proc. Natl. Acad. Sci. USA 112, 14072 - 14077

Egger, R. & Oberlaender, M. (2015) "Cell types in the cerebral cortex: an overview from the rat vibrissal cortex" In: Toga, A.W. (ed.): Brain Mapping: an Encyclopedic Reference (Amsterdam, The Netherlands: Academic Press), 59 - 64

Haberl, M.G., Silva, S.V., Guest, J.M., Ginger, M., Ghanem, A., Mulle, C., Oberlaender, M., Conzelmann, K.-K. & Frick, A. (2015) "An anterograde rabies virus vector for high-resolution large-scale reconstruction of 3D neuron morphology" Brain Struct. Funct. 220, 1369 - 1379

Narayanan, R.T., Egger, R., Johnson, A.S., Mansvelder, H.D., Sakmann, B., De Kock, C.P.J. & Oberlaender, M. (2015) "Beyond columnar organization: cell type- and target layer-specific principles of horizontal axon projection patterns in rat vibrissal cortex" Cereb. Cortex 25, 4450 - 4468

Dercksen, V.J., Hege, H.-C. & Oberlaender, M. (2014) "The filament editor: an interactive software environment for visualization, proof-editing and analysis of 3D neuron morphology" Neuroinformatics 12, 325 - 339

Egger, R., Dercksen, V.J., De Kock, C.P.J. & Oberlaender, M. (2014) "Reverse engineering the 3D structure and sensory-evoked signal flow of rat vibrissal cortex" In: Cuntz, H. (ed.): The Computing Dendrite: form Structure to Function (New York, NY, USA: Springer), 127 – 145

Egger, R., Dercksen, V.J., Udvary, D., Hege, H.-C. & Oberlaender, M. (2014) "Generation of dense statistical connectomes from sparse morphological data" Front. Neuroanat. 8, 1 - 18

Meyer, H.S., Egger, R., Guest, J.M., Foerster, R., Reissl, S. & Oberlaender, M. (2013) "Cellular organization of cortical barrel columns is whisker-specific" Proc. Natl. Acad. Sci. USA 110, 19113 - 19118

Dercksen, V.J., Oberlaender, M., Sakmann, B. & Hege, H. C. (2012) "Interactive visualization-A Key prerequisite for reconstruction and analysis of anatomically realistic neural networks" In: Linsen, L. (ed.): Visualization in medicine and life sciences II (Berlin: Springer), 27 - 44

Egger, R., Narayanan, R.T., De Kock, C.P.J. & Oberlaender, M. (2012) "3D reconstruction and standardization of the rat vibrissal cortex for precise registration of single neuron morphology" PLoS Computational Biology 8, 1 - 18

Oberlaender, M., Ramirez, A. & Bruno, R.M. (2012) "Sensory experience restructures thalamocortical axons during adulthood" Neuron 74, 648 - 655

Oberlaender, M., De Kock, C.P.J., Bruno, R.M., Ramirez, A., Meyer, H.S., Dercksen, V.J., Helmstaedter, M. & Sakmann, B. (2012) "Cell type-specific three-dimensional structure of thalamocortical circuits in a column of rat vibrissal cortex" Cereb. Cortex 22, 2375 – 2391

Oberlaender, M., Boudewijns, Z.S.R.M., Mansvelder, H.D., Sakmann, B. & De Kock, C.P.J. (2011) "Three-dimensional axon morphologies of individual layer 5 neurons indicate cell type-specific intracortical pathways for whisker motion and touch" Proc. Natl. Acad. Sci. USA 108, 4188 - 4193

Boudewijns, Z.S.R., Kleele, T., Mansvelder, H.D., Sakmann, B., De Kock, C.P.J. & Oberlaender, M. (2011) "Semi-automated three-dimensional reconstructions of individual neurons reveal cell type-specific circuits in cortex" Commun. Integr. Biol. 4, 486 - 488

Lang, S., Dercksen, V.J., Sakmann, B. & Oberlaender, M. (2011) "Simulation of signal flow in 3D reconstructions of an anatomically realistic neural network in rat vibrissal cortex" Neural Netw. 24, 998 - 1011

Kleinfeld, D., Bharioke, A., Blinder, P., Bock, D.D., Briggman, K.L., Chklovskii, D.B., Denk, W., Helmstadter, M., Kaufhold, J.P., Lee, W.-C.A., Meyer, H.S., Micheva, K.D., Oberlaender, M., Prohaska, S., Reid, R.C., Smith, S.J., Takemura, S., Tsai, P.S. & Sackmann, B. (2011) "Large-scale automated histology in the pursuit of connectomes" J. Neurosci. 31, 16125 - 16138

Meyer, H.S., Wimmer, V.C., Oberlaender, M., De Kock, C.P.J., Sakmann, B. & Helmstaedter, M. (2010) "Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex" Cereb. Cortex 20, 2277 - 2286