Structural Dynamics of Proteins

Max Planck Research Group

We focus on the application of electron microscopy to investigate the dynamics of proteins.

Publications

Said, N., Krupp, F., Anedchenko, E., Santos, K.F., Dybkov, O., Huang, Y.H., Lee, C.T., Behrmann, E., Bürger, J., Mielke, T., Loerke, J., Urlaub, H., Spahn, C.M.T., Weber, G. & Wahl, M.C. (2017) "Structural basis for λN-dependent processive transcription antitermination" Nat. Microbiol. 2, 17062

Hagelueken, G., Hoffmann, J., Schubert, E., Duthie, F. G., Florin, N., Konrad, L., Imhof, D., Behrmann, E., Morgner, N. &  Schiemann, O. (2016) "Studies on the X-Ray and Solution Structure of FeoB from Escherichia coli BL21" Biophys. J. 110, 2642-2650

Kirmizialtin, S., Loerke, J., Behrmann, E., Spahn, C.M.T. &  Sanbonmatsu, K.Y. (2015) "Chapter Sixteen - Using Molecular Simulation to Model High-Resolution Cryo-EM Reconstructions"  In: Sarah, A.W. (ed.): Methods in Enzymology (Academic Press), 497-514

Behrmann, E., Loerke, J., Budkevich, T.V., Yamamoto, K., Schmidt, A., Penczek, P.A., Vos, M.R., Bürger, J., Mielke, T., Scheerer, P. &  Spahn, C.M.T. (2015) "Structural Snapshots of Actively Translating Human Ribosomes" Cell 161, 845-857

Shah, C., Hegde, B.G., Morén, B., Behrmann, E., Mielke, T., Moenke, G., Spahn, C.M.T., Lundmark, R., Daumke, O. & Langen, R. (2014) "Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2" Structure 22, 409-420

Yamamoto, H., Unbehaun, A., Loerke, J., Behrmann, E., Collier, M., Burger, J., Mielke, T. & Spahn, C.M.T. (2014) "Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA" Nat. Struct. Mol. Biol. 21, 721-727

Budkevich, T.V., Giesebrecht, J., Behrmann, E., Loerke, J., Ramrath, D.J., Mielke, T., Ismer, J., Hildebrand, P.W., Tung, C.S., Nierhaus, K.H., Sanbonmatsu, K.Y. & Spahn, C.M. (2014) "Regulation of the mammalian elongation cycle by subunit rolling: a eukaryotic-specific ribosome rearrangement" Cell 158, 121-131

Schönichen, A., Mannherz, H.G., Behrmann, E., Mazur, A.J., Kühn, S., Silvàn, U., Schoenenberger, C.A., Fackler, O.T., Raunser, S., Dehmelt, L. & Geyer, M. (2013) "FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers" J. Cell. Sci. 126, 1891-1901

Sot, B., Behrmann, E., Raunser, S. & Wittinghofer, A. (2013) "Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes" Proc. Natl. Acad. Sci. USA 110, 111-116

Taft, M.H., Behrmann, E., Munske-Weidemann, L.C., Thiel, C., Raunser, S. & Manstein, D.J. (2013) "Functional characterization of human myosin-18A and its interaction with F-actin and GOLPH3" J. Biol. Chem. 288, 30029-30041

Behrmann, E., Müller, M., Penczek, P.A., Mannherz, H.G., Manstein, D.J. & Raunser, S. (2012) "Structure of the rigor actin-tropomyosin-myosin complex" Cell 150, 327-338

Behrmann, E., Tao, G., Stokes, D.L., Egelman, E.H., Raunser, S. & Penczek, P.A. (2012) "Real-space processing of helical filaments in SPARX" J. Struct. Biol. 177, 302-313

Hernandez, J.M., Stein, A., Behrmann, E., Riedel, D., Cypionka, A., Farsi, Z., Walla, P.J., Raunser, S. & Jahn, R. (2012) "Membrane fusion intermediates via directional and full assembly of the SNARE complex" Science 336, 1581-1584

Chua, J.J., Butkevich, E., Worseck, J.M., Kittelmann, M., Gronborg, M., Behrmann, E., Stelzl, U., Pavlos, N.J., Lalowski, M.M., Eimer, S., Wanker, E.E., Klopfenstein, D.R. & Jahn, R. (2012) "Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter" Proc. Natl. Acad. Sci. USA 109, 5862-5867

Müller, M., Mazur, A.J., Behrmann, E., Diensthuber, R.P., Radke, M.B., Qu, Z., Littwitz, C., Raunser, S., Schoenenberger, C.A., Manstein, D.J. & Mannherz, H.G. (2012) "Functional characterization of the human alpha-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy" Cell. Mol. Life Sci. 69, 3457-3479

Schneider, R., Schumacher, M.C., Mueller, H., Nand, D., Klaukien, V., Heise, H., Riedel, D., Wolf, G., Behrmann, E., Raunser, S., Seidel, R., Engelhard, M. & Baldus, M. (2011) "Structural characterization of polyglutamine fibrils by solid-state NMR spectroscopy" J. Mol. Biol. 412, 121-136